Thesis topic proposal
Mihály Kovács
Máté Varga
Creation and characterization of zebrafish models for human diseases resulting from the mutations of the RECQL4 gene


Institute: Eötvös Loránd University, Budapest
Doctoral School of Biology

Thesis supervisor: Máté Varga
co-supervisor: Mihály Kovács
Location of studies (in Hungarian): ELTE Eötvös Loránd University, Faculty of Science, Institute of Biology Department of Biochemistry and Department of Genetics
Abbreviation of location of studies: ELTE

Description of the research topic:

The goal of the proposed work is to create and characterize zebrafish models of human diseases resulting from the mutations of the RECQL4 gene (such as Baller-Gerold syndrome, Rothmund-Thomson syndrome and RAPADILINO syndrome). During her/his work the candidate will combine state-of-the-art gene editing methods and sequencing technologies with modern imaging techniques and mitochondrial functional studies. The aim of the work is to reveal how mutations in RECQL4 contribute to human disorders with such a broad phenotypic spectrum.

Required language skills: English
Further requirements: 
Further requirements: familiarity with basic molecular biology skills, previous experience with using model animals (preferably zebrafish) to model human disease

Number of students who can be accepted: 1

Deadline for application: 2023-05-31

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