Thesis supervisor: Katalin Schlett
co-supervisor: Norbert Bencsik
Location of studies (in Hungarian): ELTE Biology Doctoral School Institute of Biology, Department of Physiology and Neurobiology Abbreviation of location of studies: ELTE
Description of the research topic:
Activity-dependent changes in synapse structure and function are regulated in part by postsynaptic scaffold proteins known as molecular hubs, which are important in anchoring neurotransmitter receptors in both excitatory and inhibitory synapses. Previous research has identified alterations in the expression and function of scaffold proteins as risk factors for neurodevelopmental disorders such as autism spectrum disorder, intellectual disability or attention deficit hyperactivity disorder (ADHD). Recently we proved a previously unnoticed postsynaptic role of Caskin scaffold proteins and showed that Caskin proteins are indispensable for proper memory formation. Our recent investigations also revealed that Caskin is required for the establishment and maintenance of synaptic contacts and is needed for the correct postsynaptic localisation of excitatory glutamate receptors (Bencsik et al., 2019).
Required language skills: English Further requirements: Further requirements: Knowledge of the English language, the ability to work with animals and the applicant’s dedication, diligence and enthusiasm are essential for successful research. Previous experience in tissue and cell culture, behavioural test
Login
