Thesis supervisor: Mihály Krisztián Józsi
co-supervisor: Noémi Sándor
Location of studies (in Hungarian): ELTE TTK Institute of Biology, Department of Immunology Abbreviation of location of studies: ELTE
Description of the research topic:
The complement system is a major humoral arm of innate immunity and plays key role in the protection of the host against infections and in several other physiological processes. Inappropriate complement function and complement regulation defects can lead to tissue damage and various diseases, such as infections and inflammatory disorders. The complement regulator factor H is a major host inhibitor of complement activation; however, the role of the structurally very similar factor H-related (FHR) proteins is yet unclear. Recent data suggest that the FHR proteins rather activate complement. The PhD candidate is expected to characterize interactions of factor H family proteins, particularly the FHRs, with various host and non-host derived ligands, such as bacterial factor H-binding proteins, and design modified proteins to enhance their complement activating potential.
Required language skills: English Further requirements: Further requirements: independent thinking, proactive approach, excellent laboratory (manual) skills
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