Thesis topic proposal
Integrative Genomic and Epigenomic Analysis of Small Cell Lung Cancer Evolution


Institute: University of Szeged
theoretical medicine
Doctoral School of Interdisciplinary Medicine

Thesis supervisor: Lőrinc Sándor Pongor
Location of studies (in Hungarian): Hungarian Centre of Excellence for Molecular Medicine , Szeged, Hungary
Abbreviation of location of studies: HCEMM

Description of the research topic:

Small cell lung cancer (SCLC) accounts for 15% of all lung cancers, with short median survival and often metastatic at diagnosis. Although tumors have a good response to initial therapy, resistance is acquired soon. During treatment and the evolution of SCLC, the neuroendocrine tumor cells often change phenotype such as decreased genomic instability and switching to non-neuroendocrine state next to drug resistance. Our goal is to understand what genomic and epigenomic alterations are needed to orchestrate these phenotypic changes that lead to resistance and contribute to the short survival of SCLC patients.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2023-05-30

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