Thesis topic proposal
Csaba Pál
Deciphering evolutionary processes behind antibiotic resistance by novel tools in Synthetic Biology


Institute: University of Szeged
theoretical medicine
Doctoral School of Multidisciplinary Medical Scienses

Thesis supervisor: Csaba Pál
Web address (URL): http://group.szbk.u-szeged.hu/sysbiol/
Location of studies (in Hungarian): BRC HAS, Institute of Biochemistry, Laboratory of Microbial Experimental Evolution - Csaba Pál's Laboratory
Abbreviation of location of studies: BRC

Description of the research topic:

According to pessimistic estimates, microbial drug resistance will be the leading cause of death by 2050, unless novel antimicrobial strategies are developed. Therefore, understanding mechanisms that are underpinning antimicrobial resistance is of critical importance.
The proposed PhD project will target the systematic fine-mapping of evolutionary mechanisms that are leading to antibiotic resistance in human pathogens. As a next step, based on this knowledge we will also design novel therapeutic strategies.
The project will involve latest approaches from synthetic biology, high-throughput screening and utilize state-of-the-art sequencing technologies. For further details, please visit: http://group.szbk.u-szeged.hu/sysbiol/

Required language skills: Fluency in written and spoken
Recommended language skills (in Hungarian): English B2
Further requirements: 
Strong background in microbiology, genomics and experimental skills in molecular and synthetic biology

Number of students who can be accepted: 1

Deadline for application: 2023-06-12

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