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Thesis topic proposal
 
Multicomponent reactions for the synthesis of biologically important compounds by designed enzymes

THESIS TOPIC PROPOSAL

Institute: Budapest University of Technology and Economics
bio, environmental and chemical engineering
George A. Olah Doctoral School of Chemistry and Chemical Technology

Thesis supervisor: Péter Ábrányi-Balogh
Location of studies (in Hungarian): BME Szerves Kémia és Technológia Tanszék
Abbreviation of location of studies: BME


Description of the research topic:

Investigating the main trends in organic and medicinal chemistry, recent studies presented that only a small number of organic molecules from the whole chemistry space with poor variety have already been prepared and a limited number reactions dominate among synthetic applications. Therefore, it is highly encouraged to develop innovative chemistries such as organocatalysis, biocatalysis, C-H bond activation, metathesis, cascade reactions, click chemistry, and multicomponent reactions (MCRs). Besides, the “green” applications in organic synthesis (atomic efficiency, one-pot procedures, selective reactions) are getting important in laboratory and also in industrial practice.
The main goal of our research is the development of new (bio)synthetic pathways to biologically active compounds and new heterocyclic cores through multicomponent cascade reactions, that unify the advantages of the two approaches. Together with the design of new enzymatic pathways and the development of artificial enzymes we aim to use the toolbox of modern synthetic chemistry such as photocatalysis, C-H activation and flow chemistry. With the conscious implementation of new chemistries, reaction design and catalytic initiatives, we are trying to broaden the known chemical space.

Number of students who can be accepted: 1

Deadline for application: 2023-01-08


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
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