Thesis supervisor: Andrea Ciliberto
Location of studies (in Hungarian): PPKE - IFOM Abbreviation of location of studies: IFOM
Description of the research topic:
Cell division is the very fundamental property whereby two daughter cells originate from one mother cell. Without cell division, life cannot exist. Yet, uncontrolled proliferation underlies serious diseases such as cancer. Drugs that arrest cell proliferation are often used to treat this condition. Many drugs initially manage to slow down cell division. However, on the long run often cells recover the ability of dividing, regardless of the presence of drugs. Cells apply different strategies, at different time-scales, to circumvent the effect of these anti-mitotic drugs. We investigate how cells escape from the arrest induced by drug treatment with a combination of experimental and theoretical approaches. In particular, we perform live-cell imaging experiments using microfluidics devices, and we use also classical cell biology techniques, next-generation sequencing, and long-term lab evolution experiments. Projects involve both an experimental and a data-analysis/modeling part, depending on the curiosity and skills of the candidate.
Required language skills: Intermediate english Recommended language skills (in Hungarian): advanced english Further requirements: Knowledge of one of the topics(i)--(iiii): (i) programming in R, Python or Matlab. (ii) biology: molecular biology techniques, microscopy, yeast genetics.(iii) mathematics: dynamical systems theory and particularly ordinary differrential equuations
Number of students who can be accepted: 1
Deadline for application: 2023-01-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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