Thesis supervisor: Ákos Csonka
Location of studies (in Hungarian): University of Szeged Faculty of Medicine Department of Traumatology Abbreviation of location of studies: TRAUM
Description of the research topic:
The drug resistance most probably arises through a selection process, with the emergence of dominant clones from pools of heterogeneous tumor cells. The main mechanisms of drug resistance of tumor cells are a decrease in drug accumulation, drug resistance mediated by detoxification of the drug in the cell, alterations of drug targets or through enhancement of target repair, and alterations in genes controlling apoptosis. One of the most important drug resistance mechanisms of tumor cells is the decrease of drug accumulation by membrane-localized transporters. Modulation of efflux pump-related mechanisms by newly developed efflux pump inhibitors, in order to increase the activity of existing chemotherapeutics to which cancer becomes resistant, is one of the possible ways to overcome resistance.
Required language skills: english Number of students who can be accepted: 1
Deadline for application: 2023-01-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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