Thesis supervisor: András Dinnyés
Location of studies (in Hungarian): HCEMM-USZ StemCell Research Group; University of Szeged, Department of Cellbiology and Molecular Medicine; H-6720 Szeged, Korányi fasor 6 Abbreviation of location of studies: SZTE
Description of the research topic:
he PhD project is aimed to understand how microglia genetic diversity contribute to disease phenotype by its role in inflammatory processes and to reveal new targetable mechanism and pathways for drug development. Previously established patient-specific iPSC lines have been shown that in familial and sporadic Alzheimer’s Disease (fAD, sAD) patient cell lines in vitro neuronal models can reveal a disease phenotype. Currently it is not known if in fAD and sAD patients the genotype of microglia contributes to the disease susceptibility/progress/severity and thus would provide targetable interventional opportunities for drug development and biomarker identification. Specific research questions includes: i) the level of maturity obtained in vitro by iPSC-derived microglia, ii) AD genotype effect on the transition from M1 to M2 microglia, iii) differences in autophagic flux in patient-derived microglia.
Required language skills: English Further requirements: experience in mammalian cell cultures (preferably human) is plus
Number of students who can be accepted: 2
Deadline for application: 2022-12-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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