Thesis supervisor: Roland Patai
Location of studies (in Hungarian): Biological Research Centre, Szeged department of Biophysics Abbreviation of location of studies: BRC
Description of the research topic:
Characterization of the cellular and sub-cellular morphological changes of the neurons and non-neuronal cell types (e.g. microglia and astrocytes) have a crucial role in acute and chronic neurodegeneration. Objective morphometric parameters – which can be determined by using geometrical statistical methods – can be used as a marker of pathological functions. Our aim is to develop new and interactive platforms by adapting and automating stereological methods on a wide morphomical range from light microscopy to electron microscopic imaging. Besides the capability to assess “piece by piece” changes e.g. neuronal loss or changes in the number of synaptic connections, the platforms will be enhanced further with automated image analysis to determine physiological and pathological alterations in well-defined structures, such as microglia and their morphological polarization in neuroinflammation or remodeling of the mitochondrial structures under oxidative stress. By combining the geometrical statistics with cutting-edge image analysis, a high-throughput application can be achieved to examine multiple morphometric parameters in different neuroanatomical regions simultaneously.
Required language skills: english
Deadline for application: 2023-01-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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