Thesis supervisor: Péter Csermely
Location of studies (in Hungarian): Semmelweis Egyetem Abbreviation of location of studies: SE
Description of the research topic:
Network science is an extensively developing field, which can be used to examine complex systems, for example such intracellular mechanisms as liquid-liquid phase separation (LLPS). Eukaryotic cells are compartmentalized in order to facilitate biological processes. These compartments can be classified into membrane-bound (mitochondria, ER, Golgi, etc.) and membraneless organelles (MLOs). MLOs are built of proteins, nucleic acids and other supramolecular components through reversible LLPS. They are located both in the nucleus (e.g. nucleolus) and in the cytoplasm (e.g. stress granules, centrioles).
Altough these entities have been identified for decades, nor their exact molecular biological function neither their way of formation are entirely understood. In recent years, the role of MLOs have been described in cellular stress response, regulation of gene expression and signal transduction. The condensates formed via LLPS can irrevesibly transition into pathological aggregates, possibly leading to several neurodegenerative diseases and many types of cancer. Examination of LLPS using network science tools may contribute to reveal the exact role of its regulatory elements.
Research plan includes:
• Examination of the network topological role of LLPS-related proteins (drivers, co-drivers, regulators and clients) in human interactomes (PPi-networks) and signaling networks.
• Analyzing the role of LLPS-related proteins in cancer networks using transcriptomics and proteomics data.
• Modeling phase separation by changing the structural organization of the interactome.
• Identification of potential LLPS-related drug targets identified by comparative network topological methods.
Deadline for application: 2022-10-10
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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