ODT - THESIS TOPIC: Róbert Adalbert: Mechanisms of axon degeneration ...


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Thesis topic proposal

Mechanisms of axon degeneration in ageing and disease

THESIS TOPIC PROPOSAL

Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Róbert Adalbert
Location of studies (in Hungarian): University of Szeged, Faculty of Medicine, Department of Anatomy Histology and Embriology
Abbreviation of location of studies: Anath

Description of the research topic:

Many of the challenges axons face relate to their extreme length. Axons have a higher risk of focal transport blocks (e.g. injury, inflammation), present a larger target for diffuse transport impairment (e.g. in poorly oxygenated tissue or genetic disorders) and require longer to deliver cargoes to their terminals. This project is designed to understand the mechanisms of axon loss during normal ageing and neurodegenerative diseases. Unravelling these pathways could be the key to finding novel therapeutic targets.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2022-06-30