Thesis supervisor: Lajos Haracska
Location of studies (in Hungarian): HCEMM BRC Abbreviation of location of studies: HCEMM
Description of the research topic:
Early detection, diagnostics, and treatment of tumours is one of the greatest healthcare challenges of our days. The biopsy-based tumour diagnostic methods used most frequently are invasive, costly, and often pose a risk. The widespread of next-generation sequencing techniques enabled the application of minimally invasive procedures such as liquid biopsy, with which tumour diagnostics is performed by analysing the cell-free circulating tumour DNA in blood. This way, genetic and molecular changes that take place in the tumour cells can be mapped, tumours can be detected early, personalized therapy can be specified, relapses can be monitored, and the mechanisms leading to tumorigenesis can be revealed.
In our research, we analyse the mutations (point mutations, insertions, deletions, copy number variations) characteristic of tumour cells, using liquid biopsy, thus gaining information on tumour progression and resistance to certain drugs. Our main aim is to develop more sensitive molecular biological and bioinformatic methods that enable more precise detection, assist oncologists in choosing the appropriate therapy and understanding the molecular genetic background of tumour development, with special regard to breast, colon, and prostate tumours.
Number of students who can be accepted: 1
Deadline for application: 2022-06-30
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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