Thesis supervisor: Dóra Reglődi
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Soon after the discovery of PACAP in 1989, it was found that PACAP has neuroprotective effects. Our research group has shown these effects in animal models of several diseases of the nervous system, such as Parkinson`s disease, Huntington chorea, stroke, excitotoxic neuronal lesions and retinal degeneration. We have later described that these effects are not limited to nerve cells, but can be shown in various peripheral tissues and cells. Among others, PACAP has protective effects against oxidative stress in endothelial cells and cardiomyocytes. One of our main topics is the investigation of the cytoprotective mechanism. We are investigating the antiapoptotic and anti-inflammatory effects, using molecular biological methods. Furthermore, we study the effects of PACAP and its fragments and peptide variants on the apoptotic pathways in neuronal diseases in in vitro and in vivo models. Using peptide analogs and shorter fragments could make the in vivo use of PACAP more feasible. We also study the changes in the expression profile of PACAP and its receptors following nervous system and peripheral lesions.
Number of students who can be accepted: 1
Deadline for application: 2022-05-20
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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