Thesis supervisor: Andrea Tamás
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
PACAP is a pleiotropic and multifunctional neuropeptide, having important roles in various physiological processes. Numerous studies have shown its anti-inflammatory, neuro- and general cytoprotective effects. Increasing evidence shows that plasma PACAP levels and PACAP in several other tissue samples change under different physiological and pathological conditions suggesting the potential clinical use of PACAP as a diagnostic and prognostic biomarker in certain diseases. Most of these data were published in the last few years, showing that it is a rapidly developing research field. We also published several data about PACAP measurements in different physiological and pathological conditions. Elevated PACAP levels were measured in pregnancy and in lactating women. We showed, for the first time, the presence of PACAP in breast milk and the changes during different periods of lactation. We found significant changes in PACAP levels in severe traumatic brain injury, ischemic heart disease, lung, kidney and colon cancers. In this proposal we will focus on clinical collaborations where preliminary data showed significant alterations in PACAP levels such as neurological, cardiovascular, endocrinological and neoplastic disorders to identify the prognostic and/or diagnostic biomarker value of PACAP for diseases affecting a large population. We aim to examine PACAP and its receptor allele polymorphism in different disorders, especially in the Roma minority that shows an accelerated aging with different co-morbidities and higher mortality. We also continue the examination of human milk samples to find new potential biomarkers for immunological and allergic alterations in childhood.
Number of students who can be accepted: 1
Deadline for application: 2022-05-20
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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