Thesis supervisor: Zoltán Tigyi
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Which virulence factor-patterns characteristic for the different clinical (i.e. urine, blood, wound, respiratory) tract and non-clinical (i.e. commensal and sewage) isolate types. The isolates will be tested for proven and putative virulence factors as follows: iron uptake systems (siderophors), fimbrial and non-fimbrial adhesins, biofilm production, serum resistance, plasmid profile analysis, invasion adhesion to eukaryotic cells, connective tissue matrix binding capacity. Putative virulence genes: allS, (allantoin syntesis), kfuB (klebsiella feri uptake system), rmpA (regulator of mucoid phenotype),pks, (Polyketid syntas colibaktin) etc. Applied strain typing methods: random amplified polymorphic DNA (RAPD-PCR), Enterobacterial Repetitive Intergenic Consensus Sequnce (ERIC- PCR), Pulsed Field Gel Electrophoreses (PFGE). Further typing of selected strains on the basis of phylogenetic tree of PFGE by help of Multi Locus Sequence Typing (MLST) to reveal further connections among the clones or clusters.
Number of students who can be accepted: 1
Deadline for application: 2022-05-20
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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