Thesis supervisor: László Lénárd
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
The incidence of feeding related disorders (obesity, bulimia and anorexia nervosa) and appearance of related secondary diseases (arteriosclerosis, diabetes mellitus, and stroke) have increased dramatically world-wide. Utilization of experimental animal models studying central regulatory processes of feeding may contribute to the better understanding of these diseases and can result in the elaboration of new treatment strategies. The main goal of the experiments is to study the role of orexigenic and anorexigenic neuropeptides (orexins, bombesin like peptides, ghrelin, galanin and others) in the limbic system. By means of multibarreled microelectrophoretic method effects of orexigenic and anorexigenic peptides and their antagonists will be examined on neuronal activity and on the activity of the so called glucose monitoring neurons. After intracerebral microinjections body weight, food and water intake, as well as the microstructure of feeding, development of satiation and the level of metabolic parameters will be studied. Reinforcing effects of neuropeptides will be studied during food rewarded alimentary conditioning, and also in different rewarding and punishing paradigms. Results may cast light on the complex peptidergic central regulatory processes of feeding.
Number of students who can be accepted: 1
Deadline for application: 2022-05-20
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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