Thesis supervisor: Györgyi Váradi
Location of studies (in Hungarian): SZTE, ÁOK, Orvosi Vegytan Abbreviation of location of studies: OV
Description of the research topic:
Fungal infections have dramatically increased in recent years. It can mostly be explained by the growing number of immunocompromised patients, as well as resistance development against used drugs. To treat infections successfully, and, to develop new, effective therapeutic agents, it is important to know the mode of action of naturally-occurring antifungal peptides and proteins. Our research aims to examine defensin-like antifungal proteins produced by filamentous ascomycetes. These are relatively small proteins (containing 50-60 amino acids) having cationic character, and their structures are stabilized by 3 or 4 disulfide bridges. Methods are worked out for the chemical synthesis of the proteins, which – in many cases - can also prove the disulfide bond pattern. The parts of the proteins involved in antifungal effect are mapped, and, through modifications of these regions, smaller, effective antifungal agents are designed and synthesized. Applied methods and techniques: solid-phase peptide synthesis, solution phase syntheses (e.g., native chemical ligation, selective formation of disulfide bridges), RP-HPLC, MS and LC-MS.
Number of students who can be accepted: 1
Deadline for application: 2022-02-01
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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