Thesis topic proposal
Miklós Nagy
Development of smart fluorescent molecules


Institute: University of Miskolc
material sciences
Antal Kerpely Doctoral School of Materials Science and Technology

Thesis supervisor: Miklós Nagy
Location of studies (in Hungarian): University of Miskolc Faculty of Materials Science and Engineering
Abbreviation of location of studies: MEMAK

Description of the research topic:

"One of the core areas of today's material science research is the preparation and investigation of intelligent materials, tools that respond to environmental stimuli similarly to living systems. An exceptionally important group of them is the solvatochromic fluorescent smart materials, which respond to external stimuli by altering the wavelength or intensity of their emitted light. Despite their wide range of practical applications, the number of available solvatromic fluorophores and polymer-based systems is very limited.
We were the first to discover the group of amino isocyanonaphthalenes (ICANs) and still to this day we are pioneers this field. Our aim is to extend the field of application by utilizing other base aromatic rings than naphthalene (anthracene, fluorine, acridine) and by changing the relative position of and the amino and isocyano groups. We are looking for new low molecular weight, non-toxic, low-cost compounds suitable for metal ion detection and/or the neutralization of potentially toxic metal ions (eg mercury). Our ICAN derivatives, with reactive functional groups, may be useful for detecting specific cellular processes indicative for the early diagnosis of cancer, or utilizing fluorescence labeling to locate cancer cells. Our compounds containing acridine base ring exhibit phototoxic properties, allowing them to be used in treatments that are less harmful than conventional chemotherapy. In addition, we plan the preparation and investigation of solvatochromic homo- and copolymers, amphiphilic polymer systems, and / or nanoparticles with easily fine-tunable fluorescent properties, as well as polymer-based nonlinear optical systems are also envisaged."

Required language skills: English B2
Number of students who can be accepted: 1

Deadline for application: 2022-01-15

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