Thesis supervisor: Andrea Orosz
Web address (URL): http://web.med.u-szeged.hu/phcol/index_a.htm Location of studies (in Hungarian): Department of Pharmacology and Pharmacotherapy, Faculty of Medicine Abbreviation of location of studies: SZTE
Description of the research topic:
A number of human clinical and animal experimental studies have shown that various pathological settings cause electrophysiological remodeling in the heart, involving the altered expression of different ion channels, including the downregulation of potassium channels critical for repolarization. These changes have been associated with increased incidence of serious ventricular arrhythmias probably due to decreased repolarization reserve. It is conceivable that prolonged repolarization and a possibly impaired repolarization reserve might represent increased risk for the development of ventricular arrhythmias, including Torsades de Pointes ventricular tachycardia (TdP) that can degenerate into ventricular fibrillation and lead to sudden cardiac death (SCD). The identification of patients at risk for serious ventricular arrhythmia and SCD is critically important. Current techniques for the reliable prediction of TdP and other, potentially fatal ventricular arrhythmias remain unsatisfactory. Electrocardiographic parameters have been studied for their utility as prognostic non-invasive biomarkers in SCD risk assessment.
The aims of this research program are to investigate and to compare different conventional and novel parameters of cardiac ventricular repolarization (QT variability) determined by body-surface electrocardiogram in different clinical conditions associated with abnormal ventricular repolarization (e.g. long QT syndrome, hypertrophic cardiomyopathy, diabetes mellitus, athlete’s heart etc.) and to better identify the risk that predispose to ventricular arrhythmias and sudden cardiac death.
Required language skills: English B2 Number of students who can be accepted: 1
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