Thesis supervisor: Sándor Szűcs
Location of studies (in Hungarian): UD FM Department of Public Health and Epiodemiology Abbreviation of location of studies: ÁOKNJ
Description of the research topic:
Aliphatic alcohols in spirits are consumed in many parts of the world however, concern about exposure to these substances can be considerable in certain countries where the level of spirit consumption is high. Compared to ethanol, aliphatic alcohols have greater hepatotoxic effects. It has been suggested that this may contribute to premature mortality from chronic liver diseases and cirrhosis. Previous studies have confirmed that alcohol abuse can also lead to immunosuppression and thereby increased susceptibility to infectious diseases. As monocytes play a crucial role in killing of pathogenic microorganisms, changes in their functional state have been invoked as a factor in the impaired antimicrobial defence observed in alcohol abusers. Aliphatic alcohols detected in spirits and their metabolites may also induce gene expression in human monocytes. Therefore, the aim of our study is to investigate the effects of these alcohols and their metabolites on human monocytes by measuring migration, cytokine gene expression, and production by the cells, as well as the influence of aliphatic alcohols and their metabolites on the differentiation of monocytes to macrophages and the mechanisms which may be involved in the regulation of the above-mentioned processes.
Required language skills: English Further requirements: One of those:MSc in chemistry, MSc in molecular biology, diploma in general medicine, diploma in pharmacy, MS Office Word, Excel, Outlook, PowerPoint, proficiency in cellular and molecular biology laboratory wor
Number of students who can be accepted: 1
Deadline for application: 2021-11-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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