Thesis topic proposal
Studying directed differentiation and senescence of mesenchymal stem cells


Institute: University of Szeged
theoretical medicine
Doctoral School of Interdisciplinary Medicine

Thesis supervisor: Lajos Haracska
Location of studies (in Hungarian): SZBK
Abbreviation of location of studies: SZBK

Description of the research topic:

Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating in various directions when treated with inducers in in vitro cultures, thus providing a promising therapeutic approach in medicine. Due to their excellent regenerative capacity, MSCs may prove to be useful in the treatment of various diseases accompanied by cell and tissue damage.
Utilizing the multidirectional differentiation capacity of these stem cells, the present research analyses their bone-, cartilage-, and adipocyte-directed differentiation. The employment of stem cells may be limited by the fact that, following a number of divisions, their characteristics change, and they become senescent; division stops. The speed of their aging may be related to the age and health condition of the donor and several genetic and environmental factors as well. A further major aim of our research is to map the genetic and epigenetic background of the processes of aging by studying MSCs. During the project, we focus on revealing the role of transcriptomic, epigenetic and DNA repair factors in aging.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2021-12-31

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )