Thesis supervisor: István Andó
co-supervisor: Gyöngyi Ilona Cinege
Location of studies (in Hungarian): Institute of Genetics, Laboratory of Innate Immunity Abbreviation of location of studies: SZBK
Description of the research topic:
The approaches used in the framework of the Project will elucidate the molecular basis of the highly efficient immune response in several Drosophila species which mount an immune response with the
involvement of the multinucleated giant hemocyte, discovered in our laboratory. The data generated by a single cell transcriptome analysis will be used in a genetic system specifically developed for the
representative, Drosophila ananassae. Also, as the involvement of a horizontally transferred gene is implicated in the resistance to parasite attack, we will examine its possible link to the effective defense
processes and the involvement of multinucleated giant hemocytes. The efficient defense could also be mediated by the observed release of anucleated vesicular structures and actively moving cytoplasmic
fragments in the resistant species, we will address the question, how these structures may contribute to the efficient defense. The release, the docking and the cargo ofthese particles will be analyzed using immunological and biochemical techniques. We anticipate that the analysis will lead to the definition of novel mechanisms of innate immunity in general.
Required language skills: English Number of students who can be accepted: 1
Deadline for application: 2021-09-01
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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