Thesis supervisor: László Bodai
co-supervisor: Nóra Zsindely
Location of studies (in Hungarian): University of Szeged, Faculty of Science and Informatics, Department of Biochemistry and Molecular Biology Abbreviation of location of studies: SzTE
Description of the research topic:
Several neurodegenerative disorders, like Alzheimer, Parkinson or Huntington disease are caused by structurally abnormal and/or misfolded proteins. These proteopathies are characterized by aggregation of abnormal proteins and multifaceted pathomechansims affecting several molecular processes, which are still not clearly elucidated. Our research goal is to investigate the molecular background of protein misfolding induced neurodegeneration, focusing on (1) identification and characterization of proteopathy associated non-coding RNAs (miRNAs and long non-coding RNAs), and (2) the role of aging pathways, especially the IIS pathway in protein misfolding induced pathology. We plan to use Drosophila models of Huntington and Alzheimer disease in our experiments.
Required language skills: English Recommended language skills (in Hungarian): English Further requirements: Hands-on experience in methods of molecular biology and genetics. Capability of independent interpretation of scientific literature.