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Thesis topic proposal
 
Gut region-dependent histological, ultrastructural and molecular investigation of the enteric nervous system in diabetic animal models

THESIS TOPIC PROPOSAL

Institute: University of Szeged
biology
Doctoral School of Biology

Thesis supervisor: Mária Bagyánszki
Location of studies (in Hungarian): University of Szeged, Dept. of Physiology, Anatomy and Neuroscience
Abbreviation of location of studies: SzTE


Description of the research topic:

The variety of microbial stimuli are essential in signals starting from the microbiota-mucosal interface to enteric neurons and influence the neuronal function via extensive neuro-immune interactions in different parts of the gastrointestinal tract.
Therefore, our aim to reveal such cellular and molecular mechanisms which are critical in resulting region-specific nitrergic neuropathy in diabetic and insulin-treated diabetic rats.
During the investigation of the bidirectional communication among the gut microbiota as well as the enterocytes, intestinal immune cells and enteric neurons we try to find answers for these questions:
Which alterations can be occurred in:
- the epithelium of mucosa,
- the different immune cells of mucosa,
- the submucosal and myenteric neurons,
- the microenvironment of submucosal and myenteric ganglia?

Required language skills: English
Recommended language skills (in Hungarian): English
Further requirements: 
MSc (biologist, biology teacher, veterinarian)/MD degree

Number of students who can be accepted: 1

Deadline for application: 2021-09-01


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
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