Thesis supervisor: Elek Attila Farkas
co-supervisor: István Krizbai
Location of studies (in Hungarian): ELKH, Biological Research Center Abbreviation of location of studies: SZBK
Description of the research topic:
Aging profoundly affects the brain capillary network as the decreased capillary density fails to maintain global blood flow despite compensatory increase in capillary diameters. At the same time, the number of senescent endothelial cells increase with age. These cells are incapable of proliferation and thus incapable of repairing damaged endothelium or form new vessels. Circulating endothelial precursor cells (EPC) are able to form new blood vessels in place of vessels lost to hypoxic injury in stroke and thus boost the regeneration of brain tissue. How EPCs integrate into existing blood vessels is not well understood. Therefore, we are going to study the integration dynamics and the intercellular communication during integration of circulating EPCs in old mice with senescent endothelium and in mice undergoing experimental ischemia. In our experiments we will use fluorescently labelled EPCs and advanced superresolution microscopy and intravital two-photon microscopy.
Required language skills: English Recommended language skills (in Hungarian): English Number of students who can be accepted: 2
Deadline for application: 2021-09-01
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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