Thesis supervisor: György Tibor Balogh
Location of studies (in Hungarian): BME Szerves Kémia és Technológia Tanszék Abbreviation of location of studies: BME
Description of the research topic:
The PhD research focuses on the development of scalable flow chemistry-based methods for drug metabolite identification and synthesis. The background of this study is that biomimetic catalysts such as synthetic metalloporphyrins are able to imitate the oxidative metabolism in human liver catalyzed by cytochrome P450 isoenzymes. The immobilization of metalloprophyrins to solid carriers can provide biomimetic catalyst system with enhanced stability and efficiency. The supported catalysts can be applied as a stable filling materials on packed bed reactors as well. The optimization opportunities of biomimetic oxidation (such as oxidizing agents, solvent mixtures, residence time etc.) will be also investigated in batch and flow-chemistry mode as well. The biomimetic reactions will be followed by LC-DAD-(MS) and NMR. The results of these research can support the early stage drug discovery and the synthesis of various API metabolites at analytical and preparative scale.
Number of students who can be accepted: 1
Deadline for application: 2020-12-10
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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