Thesis supervisor: Benjámin Sándor Gyarmati
Location of studies (in Hungarian): BME Fizikai Kémia és Anyagtudományi Tanszék Abbreviation of location of studies: BME
Description of the research topic:
Poly(amino acid)s, particularly poly(aspartic acid)s (PASPs) have been in the focus of Soft Matters Group for various biomedical applications due to their expected biocompatibility and chemical versatility. The responsive properties of hydrogels formed of PASP, including pH- and redox-dependent degree of swelling, makes them very attractive candidates in targeted drug delivery.
The PhD student joining this topic will synthesize polymers with tailored properties by using various functional groups and the resultant polymers and gels will be characterized by NMR, swelling and mechanical tests as well as drug release experiments. The effect of the presence and concentration of anionic, cationic, non-ionic and redox-sensitive groups on the stability, gel formation and responsive properties will be analysed in detail. Polymers will be utilized in the nano-size range for potential application in intracellular drug delivery. Various methods will be tested to reach the nano-size range including the synthesis in water-in-oil miniemulsion and micelle formation. Nanogels will be characterized by dynamic light scattering and zeta potential measurements and their potential uses will be demonstrated by encapsulation and release of model drugs. The work will be done in cooperation with our partners, e.g. Institute of Molecular Sciences at University of Bordeaux, Faculty of Pharmacy at Szeged University and Biological Research Centre of HAS, Szeged.
Number of students who can be accepted: 1
Deadline for application: 2020-12-10
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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