Thesis supervisor: Benjámin Sándor Gyarmati
Location of studies (in Hungarian): BME Fizikai Kémia és Anyagtudományi Tanszék Abbreviation of location of studies: BME
Description of the research topic:
Polymers are widely used pharmaceutical excipients in controlled drug delivery, but several challenges can be identified such as poorly reproducible properties of natural ones or the complex synthesis and the lack of biodegradability of synthetic ones. For these reasons, poly(amino acid)s, particularly poly(aspartic acid)s and polyaspartamides have been in our focus recently due to their expected biocompatibility, structure-dependent degradability and chemical versatility.
The PhD student joining this topic will perform considerable synthetic work to prepare polymers with tailored properties by using various anionic, non-ionic and cationic groups as well as thiol and protected thiol groups by direct functionalization or by thiolactone chemistry. The polymers will be characterized basically by NMR, rheometry, mechanical and adhesion tests, degradation and drug release experiments. The polymers synthesized will be used to improve bioadhesion of the formulation for further application in controlled drug delivery on mucosal membranes. The presence of thiol groups will also be exploited to stabilize the polymers in the nano-size range and to prepare nanogels for intracellular drug delivery. The work will be done in cooperation with our partners, e.g. Institute of Molecular Sciences at University of Bordeaux, Faculty of Pharmacy at Szeged University and Biological Research Centre of HAS, Szeged.
Number of students who can be accepted: 1
Deadline for application: 2020-12-10
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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