Thesis supervisor: László Poppe
Location of studies (in Hungarian): BME Szerves Kémia és Technológia Tanszék Abbreviation of location of studies: BME
Description of the research topic:
Characterization and crystallographic studies on novel enzymes - Mechanisms of enzymatic reactions using computer methods (homology modeling, ligand docking, QM / MM calculations) - Synthesis and enzyme kinetics of systematically designed ligands and inhibitors - Computer studies on chemical reactions in solution and within enzymes. The major aim of the research topic is to examine the function and selectivity of enzymes by structural investigations and computer methods. The mechanisms of ammonia-lyase-, aminomutase-, transaminase- and hydrolase-catalyzed reactions are primarily investigated at molecular level. In addition to the computer studies on enzymes, the research will be carried out with combined substrate or inhibitor synthesis, enzyme kinetics and enzyme structural investigations. International cooperation is mainly concerned with studying the mechanism of operation of ammonia-lyase and aminomutase enzymes.
Number of students who can be accepted: 1
Deadline for application: 2020-12-10
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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