ODT - THESIS TOPIC: Zsolt Kis: Histological examination of mouse ...


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Thesis topic proposal

Histological examination of mouse strains carrying null mutations of different kynurenine aminotransferase isoenzymes

THESIS TOPIC PROPOSAL

Institute: University of Szeged
biology
Doctoral School of Biology

Thesis supervisor: Zsolt Kis
Location of studies (in Hungarian): University of Szeged, Dept. of Physiology, Anatomy and Neuroscience
Abbreviation of location of studies: SZTE

Description of the research topic:

Kynurenic acid (KYNA) is one of the neuroactive end-products of the kynurenine pathway (KP) of tryptophan (TRP) degradation in the mammalian brain. Its presence, changes in production, its potential neuroprotective and neuromodulatory effects in the central nervous system are not fully understood. Four isoforms of kynurenine aminotransferase (KAT) enzymes are responsible for the conversion of L-kynurenine to KYNA. The aim of our study is to map the localization of KAT isoforms in brain regions affected by various neurodegenerative diseases. These assays are performed in wild-type and mouse strains carrying zero mutation of isoenzymes.

Required language skills: English
Number of students who can be accepted: 2

Deadline for application: 2020-12-31

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).