Login
 Forum
 
 
Thesis topic proposal
 
Balázs Gergely Madas
Modelling of low dose hyper-radiosensitivity and induced radioresistance

THESIS TOPIC PROPOSAL

Institute: University of Pannonia
environmental sciences
Doctoral School of Chemistry and Environmental Sciences

Thesis supervisor: Balázs Gergely Madas
Location of studies (in Hungarian): Environmental Physics Department, Centre for Energy Research, Budapest
Abbreviation of location of studies: MTAEP


Description of the research topic:

Low-dose hyper-radiosensitivity (HRS) and increased radioresistance (IRR) have been observed in many different cell lines in vitro and in skin in vivo. It means that cell survival does not decrease monotonically as the function of radiation dose, but shows a local minimum. The underlying mechanisms of these phenomena are quite unclear. There is evidence, however, suggesting that they are the result of biological regulations (increased apoptosis at HRS, increased DNA damage repair at IRR). The objective of the research is to find out whether there are any quantifiable advantages of these phenomena at the tissue level with particular attention on mutation induction, cancer risk, and their implications on radiation protection and radiation therapy.

Required language skills: english
Further requirements: 
MSc in a quantitative field, strong interest in biology, good communication skills in English, both spoken and written

Number of students who can be accepted: 1

Deadline for application: 2021-01-31


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )