Thesis supervisor: András Dinnyés
Location of studies (in Hungarian): SZTE ÁOK Bőrgyógyászati és Allergológiai Klinia Abbreviation of location of studies: BŐRKL
Description of the research topic:
The PhD project is aimed to understand how microglia genetic diversity contribute to diseasephenotype by its role in inflammatory processes and to reveal new targetable mechanism andpathways for drug development. Previously established patient-specific iPSC lines have beenshown that in familial and sporadic Alzheimer’s Disease (fAD, sAD) patient cell lines in vitroneuronal models can reveal a disease phenotype. Currently it is not known if in fAD and sADpatients the genotype of microglia contributes to the disease susceptibility/progress/severityand thus would provide targetable interventional opportunities for drug development andbiomarker identification. Specific research questions includes: i) the level of maturityobtained in vitro by iPSC-derived microglia, ii) AD genotype effect on the transition from M1to M2 microglia, iii) differences in autophagic flux in patient-derived microglia
Deadline for application: 2021-01-17
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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