Thesis topic proposal
Péter Antal-Szalmás
Evaluation of the antigenicity of anti-neutrophil cytoplasmic antibodies (ANCA) - identification of novel antigens


Institute: University of Debrecen
clinical medicine
Gyula Petrányi Doctoral School of Allergy and Clinical Immunology

Thesis supervisor: Péter Antal-Szalmás
Location of studies (in Hungarian): DE, ÁOK, Laboratóriumi Medicina Intézet
Abbreviation of location of studies: LMI

Description of the research topic:

ANCAs are pathological autoantibodies the presence of which is associated with certain types of vasculitides and other autoimmune disorders. The antibodies recognize antigens localized in the cytoplasm of neutrophil granulocytes. Using different immunological techniques 3 major types of them are described: cANCA, pANCA and atypic ANCA. Since antigen specificity of atypic ANCA is hardly characterized, in our project we try to identify autoantigenes binding to IgG and IgA type atypic ANCA present in the sera of patients with autoimmune liver diseases and cirrhosis.

Required language skills: angol felsőfok
Recommended language skills (in Hungarian): bármilyen 2. nyelv minimum ala
Further requirements: 
jeles (summa cum laude) minősítésű alap diploma

Number of students who can be accepted: 1

Deadline for application: 2020-08-30

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