ODT - THESIS TOPIC: Zsolt Bacsó: Role of ABC transporters ...


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Thesis topic proposal

Role of ABC transporters in transmigration

THESIS TOPIC PROPOSAL

Institute: University of Debrecen
theoretical medicine
Doctoral School of Molecular Cellular and Immune Biology

Thesis supervisor: Zsolt Bacsó
Location of studies (in Hungarian): University of Debrecen
Abbreviation of location of studies: DEÁOK

Description of the research topic:

Silencing the expression or blocking the activity of the ABCB1 multidrug-resistance (MDR) transporter P-glycoprotein prevents transmigration of CD8+ lymphocytes or dendritic cells via the endothelial layers of blood or lymphatic vessels. No information is available yet about the mechanism of how MDR transporters are involved in diapedesis. Therefore, deciphering the role of MDR transporters in the extravasation or homing of immune cells especially the effector and immune-initiator ones, is of great importance in basic science and also in therapy.

Number of students who can be accepted: 1

Deadline for application: 2020-09-30

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).