Thesis supervisor: Mihály Boros
Location of studies (in Hungarian): SZTE ÁOK Sebészeti Műtéttani Intézet Abbreviation of location of studies: ÁOK
Description of the research topic:
The effects of non-steroidal anti-inflammatory drugs (NSAID) on gastrointestinal (GI) mitochondria is controversial, some drugs are inducers of dysfunction (e.g. diclofenac), while others have a protective effect (e.g. acetylsalicylic acid). Among antibiotics, macrolides, tetracyclines, fluoroquinolones and penicillines can also damage mitochondria and the eukaryotic cells by causing the dysfunction of the mitochondrial respiratory chain. Our main question targets the effects of prophylactic and anti-inflammatory GI drugs on epithelial mitochondria, the evolvement of side-effects during their usage, and finally the diagnosis and possible treatment of these side-effects. During our investigations, we aim to analyse human biopsies and mucosal samples from experimental animal model of colitis.
Techniques available: basic laboratory techniques for isolation of epithelial cells from human biopsies. In vivo animal models (rodent colitis), in vivo imaging techniques with fluorescent laser-scanning endomicroscopy or intravital microscopy. Microcirculatory measurements with orthogonal polarization spectral imaging and laser-Doppler technique. Measurement of mitochondrial respiration using high-resolution respirometer and its fluorescent modules (Oroboros O2k).
Required language skills: angol B2 komplex nyelvvizsga Recommended language skills (in Hungarian): English B2 level/TOEFL Further requirements: previous scientifical research work
Deadline for application: 2020-08-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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