ODT - THESIS TOPIC: István Ábrahám: Investigating of non-classical estrogen ...


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Thesis topic proposal

Investigating of non-classical estrogen action in the brain

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Basic Medicine

Thesis supervisor: István Ábrahám
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Estrogen secreted from the ovary alters the function of several neuronal phenotypes. Cholinergic neurons degenerate in Alzheimer's disease and estrogen plays a role in determining the vulnerability of cholinergic neurons in this condition. The estrogen also acts a feedback manner to alter the function of gonadotropin releasing hormone (GnRH) neurons, the central "processor unit" of the fertility. Although estrogen primarily alters the neuronal activity by modulating gene expression directly it also exerts "non-classical" effects on neurons by altering signal transduction pathways. In our laboratory, we are systematically characterizing the mechanism and role of estrogen-induced "non-classical" effect on signalling molecules in cholinergic and GnRH neurons using immunohistochemistry, calcium imaging, single cell electrophysiology, single molecule detection, bahavioural tests and transgenic technology.

Number of students who can be accepted: 1

Deadline for application: 2020-05-15

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).