Thesis supervisor: Péter Béla Hajdu
Location of studies (in Hungarian): University of Debrecen, Faculty of Medicine, Department of Biophysics and Cell Biology Abbreviation of location of studies: DEBSI
Description of the research topic:
Ion channels of T lymphocytes play essential role in effector functions such as activation, cytokine production and target cell killing. Kv1.3 and KCa3.1 channels in T cells stabilize the negative membrane potential required for the Ca2+ influx though the CRAC channels and the Ca2+-dependent pathway. The outcome of Ca2+-signaling essentially depends on the membrane localization and expression of these ion channels. The project aims to understand the role of T cell ion channels in physiological and pathophysiological conditions. Based on our previous results we assume that these ion channels of various T cell subtypes (effector, CAR- and regulatory T cells) a determinant of T cell functions. In our experiments we will study the function of ion channels in tumor infiltrating T cells, CAR T cells and in intratumoral Tregs isolated from a mouse model. The main methods and techniques applied are patch-clamp, fluorescent Ca2+-imaging, flow cytometry, immunohistochemistry, immunocytochemistry, confocal microscopy.
Required language skills: angol középfok Number of students who can be accepted: 2
Deadline for application: 2020-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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