Thesis topic proposal
Csaba Tömböly
Targeted cell membrane delivery of lipidated interleukins


Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Csaba Tömböly
Location of studies (in Hungarian): Laboratory of Chemical Biology, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences
Abbreviation of location of studies: BRC

Description of the research topic:

Targeted delivery of proteins without genetic methods is of great importance both in biotechnology and in medicine. Isolated GPI-anchored proteins can be transferred to the plasma membrane of diverse host cells with preserving the original protein function. However, their wide-spread application is limited by the complex structure of the glycolipid moiety that is chemically hardly accessible and that can have unknown biological functions. The responsibility of the candidate is to develop novel lipid amphiphils that can be applied as structurally simplified protein membrane anchor moieties. To achieve this goal novel bioorthogonal methods will be explored for protein lipidation, and inclusion complexes and exosomes will be studied as delivery vectors of the lipidated proteins. In pilot studies the effect of lipid modification on the immune activity of interleukins will be investigated.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-12-31

2019. IX. 13.
ODT ülés
Az ODT következő ülésére 2019. november 22-én 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

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