Thesis topic proposal
László Siklós
Investigation of ultrastructural alterations and microanalytical changes associated with degeneration of motor neurons


Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: László Siklós
Location of studies (in Hungarian): MTA SZBK Biofizikai Intézet
Abbreviation of location of studies: SZBK

Description of the research topic:

The neurodegenerative diseases, associated with progressive and relentless destruction of nerve cells are mostly incurable. The death of degenerating cells is preceded by characteristic ultrastructural and microanalytical changes, which could be disclosed by conventional and specialized electron microscopic methods. The aim of the study is the characterization of cell-autonomous and non-cell-autonomous processes underlying neurodegenerative diseases with these techniques, which induced in experimental animals either by surgical intervention, or by exposition to acute or chronic stress conditions. Furthermore, the efficacy of different drug candidates is aimed to be characterized by ultrastructural and microanalytical evaluation of their effects in prophylactic or post-traumatic treatment paradigms.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-12-31

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