Thesis topic proposal
István Krizbai
Role of the neurovascular unit in inflammatory processes of the central nervous system


Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: István Krizbai
Location of studies (in Hungarian): MTA SZBK Biofizikai Intézet
Abbreviation of location of studies: SZBK

Description of the research topic:

A functionally intact neurovascular unit (NVU) is a prerequisite for the proper functioning of the central nervous system (CNS). The most important cellular components of the NVU are cerebral endothelial cells, pericytes and astrocytic endfeet, however, other cellular elements like microglia or neurons may also play a modulatory role. Our main aim is to understand the role of pericytes and endothelial cells in different CNS processes associated with inflammation (stroke, neurodegenerative disorders, aging).
In vitro multicellular model systems and different biochemical and molecular biology and functional methods will be used to investigate the role of pattern recognition receptors and inflammasome activation in cellular components of the NVU. Advanced ex vivo (confocal microscopy, superresolution microscopy) and in vivo imaging systems (two photon microscopy) will be applied to monitor the neurovascular unit under different experimental conditions

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-12-31

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )