Thesis topic proposal
A sigma-1 receptor szerepének tanulmányozása a neurodegeneratív betegségek pathomechanizmusában, sig-1 antagonisták hatásának vizsgálata az Alzheimer-kórban.


Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Lívia Fülöp
Location of studies (in Hungarian): SZTE ÁOK Orvosi Vegytani Intézet
Abbreviation of location of studies: OVI

Description of the research topic:

According to the latest results, the sigma-1 receptor plays a key role in
the pathomechanism of most of the neurodegenerative diseases. Modulation
of the receptor may lead to a decrease of the endoplasmic reticulum
stress, which might open a new therapeutic way in the treatment of these
diseases. In the frames of the project we aim to test the effect of
putative drug candidates on the sig-1 receptor and try to identify novel
principles regarding their structure-activity relationship.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-12-31

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