Thesis topic proposal
Szilvia Veszelka
Mária Anna Deli
Targeting nanoparticles across the blood-brain barrier


Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Mária Anna Deli
co-supervisor: Szilvia Veszelka
Location of studies (in Hungarian): SZBK Biofizikai Intézet
Abbreviation of location of studies: SZBK

Description of the research topic:

Nanoparticles are promising new systems to increase drug delivery to brain. In our experiments we will decorate the surface of nanoparticles with ligands targeting solute carriers (SLC) transporting nutrients across the blood-brain barrier (BBB). These SLCs will bind the ligands and thus help the transfer of the nanoparticles or their cargo across the BBB to the brain. No study has been done so far on nanoparticles targeted with multiple ligands targeting different SLCs at the BBB. Therefore, our aim is to select the best combination of SLC ligands and thus prepare, optimize and test BBB-selective nanoparticles with unique multiple ligand pattern.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-12-31

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )