Thesis topic proposal
László Dux
Standardization and quality control of macromolecular assays in pathobiochemistry, clinical biochemistry


Institute: University of Szeged
theoretical medicine
Doctoral School of Multidisciplinary Medical Scienses

Thesis supervisor: László Dux
Web address (URL): http://www.biochem.szote.u-szeged.hu/
Location of studies (in Hungarian): Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 9., Hungary
Abbreviation of location of studies: ÁOK

Description of the research topic:

The programme provides opportunity in research and development of new measurement techniques in pathobiochemistry and clinical biochemistry, standardization and quality control of macromolecular assay methods
In this study LC-IDMS/MS (liquid chromatography isotope-dilution mass spectrometry) procedures for determination of various drug compounds (immunosuppressive, antiretrovirale) in human blood has been developed by using Cs+ adducts in the selected reaction monitoring mode (SRM). The measurement of Cs-adducts in the quantitative HPLC-MS/MS technology resulted in high analytical specificity, accuracy, and precision. The LC-IDMS/MS procedure may be considered as a candidate reference measurement procedure and is appropriate to calibrate analytical routine systems.

Required language skills: English
Recommended language skills (in Hungarian): German
Number of students who can be accepted: 1

Deadline for application: 2019-12-19

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )