Thesis topic proposal
Immunomodulatory effects of nanoparticles in the tumor microenvironment


Institute: University of Szeged
theoretical medicine
Doctoral School of Multidisciplinary Medical Scienses

Thesis supervisor: Mónika Csontné Kiricsi
Web address (URL): http://biokemia.bio.u-szeged.hu/index.html
Location of studies (in Hungarian): University of Szeged Dept. Biochemistry and Molecular Biology
Abbreviation of location of studies: TTIK

Description of the research topic:

The general strategy to treat cancer is still based on traditional chemotherapy using small molecular drugs. Although conventional chemotherapy has a decent success rate it frequently causes severe side effects and can even result in the evolution of multidrug resistant cancer phenotypes. Nanoparticle based treatment of solid tumors is regarded as a novel, attractive strategy to improve cancer therapy, since approximately 10-200 nm sized materials are selectively accumulated in tumor tissues due to the passive targeting effect, where many of them, especially metallic particles can exert direct anti-cancer activity. Owing to their large surface area nanomaterials can also serve as controllable delivery platforms of various cytotoxic drugs for active tumor targeting. Our research group investigates the cellular and molecular events behind the anti-cancer activity of different metal nanoparticles in in vitro and in vivo animal model systems. Apart from the direct effects on cancer cells we try to delineate how nanoparticles influence the molecular features of other cell types within the tumor microenvironment as well as on various cells of the immune system

Required language skills: English B2
Recommended language skills (in Hungarian): research work
Further requirements: 
TDK munka

Number of students who can be accepted: 1

Deadline for application: 2019-12-19

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )