Thesis topic proposal
Ákos Koller
Microcirculation and vascular biology: physiology/pathophysiology


Institute: Semmelweis University, Budapest
theoretical medicine
Doctoral School of Basic and Translational Medicine

Thesis supervisor: Ákos Koller
Location of studies (in Hungarian): Semmelweis Egyetem
Abbreviation of location of studies: SE

Description of the research topic:

The primarily role of tissue microcirculation (arterial and venous and including lymphatic) is to supply the tissues with gases and nutrients, to ensure the appropriate levels of metabolite exchange, in a wide range of physiological and pathological conditions. All these are done by adaptation of microvascular network geometry to the anatomical structure and function of various organs (for example, brain, muscle, skin, heart muscle, bone), and at the same time the microcirculatory system has to obey the laws of physics and hemodynamics. When necessary, the nervous and hormonal systems can override the organ-centered, local control of microcirculation to maintain the operation of the whole organism. The microcirculation and vascular wall can be affected by number of conditions, for example in response to increased physical activity sport training and in diseased conditions. Thus it is important to do research on all of these fields and thus students can carry on research in the following fields:

1) Signaling mechanisms of myogenic- and shear stress-vasomotor responses
2) Functional and morphological changes or microvessels in hypertension (essential, renal and aortic coarctation).
3) Adaptation of coronary microvessels to ischemia and infarction of cardiac muscle.
4) Role of small cerebral arteries in eh autoregulation of cerebral blood flow, in stroke, Alzheimer diseases and vascular dementia.
5) Alteration or renal microvessels to upregulation of the renin angiotensin system.
6) Changes in eh function of microvessels and vascular biology in metabolic diseases (DM, hyperhomocysteinemia, etc.)
7) Adaptation of microvessels to increased physical activity and sport training: role of endothélium and smooth muscle.

For all these reasons, research of the microcirculation is not only exciting, but it is essential to understand the healthy adaptation and clinical pathologies of microvessels at functional and molecular levels, which can lead to the discovery of novel treatment modalities.

Number of students who can be accepted: 3

Deadline for application: 2019-12-31

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