ODT - THESIS TOPIC: Elek Attila Farkas: Role of the neurovascular ...


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Thesis topic proposal

Role of the neurovascular unit in inflammatory processes of the central nervous system

THESIS TOPIC PROPOSAL

Institute: University of Szeged
biology
Doctoral School of Biology

Thesis supervisor: Elek Attila Farkas
Location of studies (in Hungarian): Biological Research Centre, Hungarian Academy of Sciences
Abbreviation of location of studies: SzBK

Description of the research topic:

A functional neurovascular unit (NVU) is a prerequisite for a properly functioning central nervous system (CNS). The most important cellular components of the NVU are cerebral endothelial cells, pericytes and astrocytic endfeet, however, other cellular elements such as microglia or neurons may also play a modulatory role.
Our main aim is to understand the role of pericytes and endothelial cells in different CNS processes associated with inflammation: stroke, neurodegenerative disorders, aging. In vitro multicellular model systems and different molecular biology and functional methods will be used to investigate the role of pattern recognition receptors and inflammasome activation in cellular components of the NVU. Advanced ex vivo (confocal and superresolution microscopy) and in vivo (two-photon microscopy) imaging will be applied to monitor the NVU under experimental conditions.

Number of students who can be accepted: 1

Deadline for application: 2019-08-31

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).