Thesis supervisor: András Málnási Csizmadia
Location of studies (in Hungarian): Eötvös Loránd University Abbreviation of location of studies: ELTE
Description of the research topic:
"Recently we discovered the first in vivo applicable inhibitor specific to the myosin 2 motor protein. In our body there are several different myosin 2 enzymes responsible for series of physiological functions including skeletal, smooth and cardiac muscle contraction, as well as cell division, motility and neurite outgrowth, which is related to neural plasticity and regeneration. By targeting these motor proteins with specific drugs we will be capable of alleviating symptoms of stroke or helping people suffering from spasms, scarring or fibrocyte related disorders. Given its significant functions, non-muscle myosin 2 (NM2) is becoming an important therapeutic target in various diseases, including stroke, a leading cause of disability and mortality. Currently no effective therapy is available. Our laboratory has developed a biologically safe myosin 2 specific motor protein inhibitor, to repair the damaged brain tissue through the formation of vascular and neuronal networks. See more: http://www.motorpharmacology.com and http://www.malnalab.hu
The PhD candidate will characterize the pharmacological and biochemical activities of this inhibitor by in vivo, in vitro and biochemical methods. He/she will also contribute in the development of further drug candidates. "
Required language skills: English Further requirements: "We expect high motivation and good knowledge in biochemistry and/or neuronal physiology.
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Number of students who can be accepted: 1
Deadline for application: 2019-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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