ODT - THESIS TOPIC: Hajnalka Ábrahám: Neuropathological examination of the ...


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Thesis topic proposal

Neuropathological examination of the tissue surgically removed due to temporal lobe epilepsy

THESIS TOPIC PROPOSAL

Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Neurosciences

Thesis supervisor: Hajnalka Ábrahám
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Regarding the etiology, temporal lobe epilepsy can be divided into three groups: mesial temporal sclerosis-, brain tumor- and cortical developmental malformation-related epilepsies. During our work, surgically removed neo- and archicortical (hippocampal formation, subiculum, entorhinal cortex) structures due to therapy of temporal lobe epilepsies will be examined. Examinations will be carried out with light and electron microscopic methods (immunohistochemistry, immunoelectron microscopy). Our aim is to study cell death, cell proliferation, synaptic reorganization and other morphological alterations that indicate abnormal neuronal migration. We search those common morphological changes in epilesies due to different etiologies which, independently of the cause of the epilepsy, is the consequence of the hyperexcitation. We aim to discover neuropathologoical changes that may clarify the cause of epilepsy.

Number of students who can be accepted: 1

Deadline for application: 2019-05-17

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).