Thesis supervisor: Tibor Kurtán
Location of studies (in Hungarian): Department of Organic Chemistry, University of Debrecen, Debrecen, Hungary Abbreviation of location of studies: E
Description of the research topic:
Stereoselective Knoevenagel-1,5-hydride shift-cyclization and Knoevenagel-hetero-Diels-Alder cascade reactions of substituted furan and thiophene derivatives are to be carried out to prepare a small library of condensed chiral heterocycles for antiproliferative activity studies.
(2H)-chromene, furfural and thiophene-2-carbaldehyde derivatives are to be converted to precursors of domino cyclization reactions in short sequences, the reactions of which with acyclic and cyclic active methylene reagent are studied to afford different chiral scaffolds for bioactivity screening. The stereoselectivity of the reactions is to be examined by spectroscopic methods including NMR methods and chiroptical measurements, X-ray diffraction and DFT calculations. Stereochemistry-bioactivity relationships are to be identified during the bioactivity screening of different diastereomers and enantiomers.
Required language skills: english Further requirements: other expectations: organic synthetic and structural elucidation experience
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